Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?
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Oncologic Imaging - Review

Proton magnetic resonance spectroscopy in oncology: the fingerprints of cancer?

Diagn Interv Radiol 2016;22(1):75-89 DOI: 10.5152/dir.2015.15009
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Abstract

Abnormal metabolism is a key tumor hallmark. Proton magnetic resonance spectroscopy (1H-MRS) allows measurement of metabolite concentration that can be utilized to characterize tumor metabolic changes. 1H-MRS measurements of specific metabolites have been implemented in the clinic. This article performs a systematic review of image acquisition and interpretation of 1H-MRS for cancer evaluation, evaluates its strengths and limitations, and correlates metabolite peaks at 1H-MRS with diagnostic and prognostic parameters of cancer in different tumor types.